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. 2021 Jun 11;19:87. doi: 10.1186/s12958-021-00776-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — FRAP analysis of maternal histones in GV oocytes and early embryos. a FRAP recovery curves of maternally expressed H3.3-eGFP or H2B-mCherry in parental genomes at early zygote stage. Mean ± s.e.m. b Compilation of histone mobilities determined by FRAP of maternally expressed H3.3-eGFP (left) and H2B-mCherry (right) in GV oocytes, 1C-early (male), 1C-early (female), 1C-late (male), 1C-late (female), 2C-early and 2C-late embryos. Mean of 8-15 ± s.e.m. c Chromatin compaction was determined by nuclear volume per haploid genome during development from GV oocytes to late 2-cell embryos. Mean of 5 ± s.e.m. d Linear regression analysis of histone dynamics and nuclear size indicates that mobility of H3.3 instead of H2B correlates linearly with chromatin compaction status