Table 2.
Co-localization analysis with two CHD GWASs and eQTL findings
| Chro | Regions | Gene | Source for Co-localization | PP0 | PP1 | PP2 | PP3 | PP4 |
|---|---|---|---|---|---|---|---|---|
| 6 | 32,520,489–32,527,779 | HLA-DRB6 | GWAS – Phase 1 | 1.12e-10 | 0.028 | 1.95e-09 | 0 | 0.972 |
| 10 | 93,542,595–93,558,048 | TNKS2-AS1 | eQTL – Artery Aorta | 1.11e-02 | 2.11e-02 | 5.07e-04 | 0 | 0.967 |
| eQTL – Artery Tibial | 2.12e-03 | 4.04e-03 | 5.21e-04 | 0.993 | ||||
| eQTL – Heart Atrial Appendage | 1.34e-04 | 2.56e-04 | 5.24e-04 | 0.999 | ||||
| eQTL – Heart Left Ventricle | 8.05e-04 | 1.53e-03 | 5.23e-04 | 0.997 | ||||
| 14 | 77,425,980–77,432,145 | LINC01629 | eQTL – Artery Aorta | 3.70e-03 | 2.95e-02 | 1.97e-04 | 6.04e-04 | 0.966 |
| eQTL – Artery Tibial | 1.38e-07 | 1.09e-06 | 1.27e-04 | 0 | 0.999 | |||
| eQTL – Heart Artial Appendage | 3.11e-06 | 2.45e-05 | 1.27e-04 | 0 | 0.999 | |||
| 5 | 33,440,801–33,468,196 | TARS | eQTL – Artery Aorta | 2.72E-07 | 1.37e-02 | 1.95e-08 | 0 | 0.986 |
| eQTL – Artery Tibial | 2.41E-08 | 1.22e-03 | 1.97e-08 | 0 | 0.999 | |||
| 19 | 37,803,738–37,855,358 | ZNF875 | eQTL – Heart Artial Appendage | 1.93e-05 | 5.59e-07 | 3.34e-02 | 0 | 0.967 |
| eQTL – Heart Left Ventricle | 2.42e-05 | 7.01e-07 | 3.34e-02 | 0 | 0;967 | |||
| 19 | 53,362,743–53,400,947 | ZNF320 | eQTL – Artery Aorta | 1.03e-12 | 2.85e-03 | 3.50e-14 | 0 | 0.972 |
| eQTL – Artery Tibial | 6.95e-13 | 1.93e-03 | 3.53e-14 | 0 | 0.981 | |||
| 10 | 104,613,966–104,661,655 | BORCS7 / ASMT | eQTL – Artery Aorta | 1.10e-02 | 6.92e-04 | 1.55e-02 | 5.11e-06 | 0.973 |
| eQTL – Artery Tibial | 7.95e-05 | 5.00e-06 | 1.57e-02 | 0 | 0.984 |
PP0 – PP4: Bayesian posterior probability for hypotheses H0 to H4, respectively
H0: there exist no causal variants for either trait;
H1: there exists a causal variant for trait 1;
H2: there exists a causal variant for trait 2;
H3: there exist two distinct causal variants, one for each trait; or
H4: there exists a single causal variant common to both traits
HLA-DRB6: major histocompatibility complex, class II, DR beta 6
TNKS2-AS1: TNKS2 antisense RNA 1
LINC01629: long intergenic non-protein coding RNA 1629
TARS: threonyl-tRNA synthetase
ZNF875: Homo sapiens zinc finger protein 875
ZNF320: zinc finger protein 320
BORCS7 / ASMT: BLOC-1 related complex subunit 7 / acetylserotonin O- methyltransferase