Table 3.

Summary

	Low-risk HPV	Low-risk HPV + EBV	High-risk HPV + EBV
Proliferative activity	–	++	+++
DNA damage	+	+++	+++
Apoptotic suppression	–	+	++
NF-κB activation	–	++	+++
Inactivation of p53	–	++	+++
Invasive ability	–	±	+
Anchorage-independent growth	–	–	+
Tumor formation in nude mice	–	–	+
Activation of adhesion signaling including paxillin, MMP2	–	–	+