TABLE 3.

PK parameters of HTZ in the absence or presence of benzaldehyde (140 mg kg^-1).

Parameter	HTZ (17 mg kg-1)	HTZ (17 mg kg-1) + BEN (140 mg kg-1)
AUC0–6 (μg mL−1 h−1)	4.69 ± 0.63	6.11 ± 0.82a
AUC0–∞ (μg mL−1 h−1)	4.89 ± 0.81	6.41 ± 1.16a
Cmax (μg ml−1)	1.75 ± 0.11	2.60 ± 0.45a
Tmax (h)	1.42 ± 0.20	1.66 ± 0.23
MRT (h)	2.32 ± 0.18	2.15 ± 0.08

AUC0–6: area under the plasma concentration–time curve from 0 to 6 h; AUC0^–∞: area under the plasma concentration–time curve from 0 h to infinity; C_max: peak plasma concentration; T_max: time to reach peak plasma concentration; MRT: mean residence time.

^a p < 0.05 meant compared to the control group. Data are shown as the mean ± SD.