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. 2021 May 28;9:607001. doi: 10.3389/fcell.2021.607001

FIGURE 5.

FIGURE 5

miR-181d-5p reduction in hepatoma cell-derived EVs reduced the effects of BMSCs on EMT and invasion of hepatoma cells. (A) MTT assay was used to detect the proliferation ability of Huh7 and H22 cells at different time points. (B) EdU assay was used to detect the proliferation ability of Huh7 and H22 cells. (C,D) Transwell assays were used to detect the invasion and migration abilities of Huh7 and H22 cells. (E) Western blot analysis was used to detect the expression of EMT-related proteins in Huh7 and H22 cells; compared with the CM-EVs group. *p < 0.05, **p < 0.01, ***p < 0.001. Data were analyzed by one-way ANOVA, followed by Tukey’s multiple comparison test. Replicates = 3.