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. 2021 May 28;12:661072. doi: 10.3389/fphar.2021.661072

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Copyright © 2021 Yan, Ni, Sheng, Zhang, Xiao, Ma, Li, Wu and Tu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ROF blocks the activation of P38/JNK and PI3K/AKT/mTOR pathways induced by IL-1β in chondrocytes. Cells were exposed to L-1β (10 ng/ml) with or without 20 μM ROF for 30 min as above. (A) Western blots and (B) quantitative analysis of MAPK pathways in each group. (C) Western blots and (D) quantitative analysis of PI3K/AKT/mTOR pathways in each group. JNK, P38, ERK, PI3K, AKT, and mTOR were used as loading control (n = 3). #p < 0.05 vs. control group; *p < 0.05 and **p < 0.01 vs. IL-1β group.