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. 2021 May 28;9:676156. doi: 10.3389/fcell.2021.676156

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Copyright © 2021 Wang, Zhang, Xu, Xie and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The dysregulation of hub genes was correlated to the survival time in patients with esophageal adenocarcinoma (EA) and esophageal squamous cell carcinoma (ESCC). (A,B) Higher expression levels of MAPK1 were associated with longer overall survival (OS) time in patients with ESCC, not EA. (C,D) Higher expression levels of ACOX1 were associated with shorter OS time in patients with ESCC and longer OS time in patients with EA. (E,F) Higher expression levels of SCP2 were associated with shorter OS time in patients with ESCC, but not EA. (G,H) Higher expression levels of NLN were associated with shorter OS time in patients with EA, but not ESCC.