TABLE 5.
Pharmacokinetic parameters of hyzetimibe, hyzetimibe-M1,14C-hyzetimibe and 14C-hyzetimibe-M1.
| Parameter | Unit | Hyzetimibe a | 14C-hyzetimibe | Hyzetimibe-M1 a | 14C-hyzetimibe-M1 |
|---|---|---|---|---|---|
| N | — | 10 | 6 | 10 | 6 |
| Tmax | h | 1.75 (1.00, 5.00) b | 3.19 (0.250, 4.95) b | 2.00 (1.00, 2.50) b | 1.00 (0.250, 2.50) b |
| Cmax | ng/mL | 8.4 (4.4) | 2.81 (1.04) | 191.0 (72.4) | 166 (49.6) |
| AUC0-t | h × ng/mL | 106.4 (45.2) | 32.9 (11.4) | 983.4 (293.9) | 950 (303) |
| AUC0-∞ | h × ng/mL | 116.2 (45.3) | 34.3 (11.1) | 1,030.4 (302.8) | 987 (277) |
| t1/2 | h | 16.1 (4.3) | 9.13 (3.10) | 17.4 (4.9) | 9.13 (3.56) |
NOTE. Data are mean (SD) unless otherwise noted.
AUC0-t, area under the concentration-time curve from zero (predose) to the time of the last quantifiable concentration; AUC0-∞, area under concentration-time curve from zero (predose) extrapolated to infinity; Cmax, maximum plasma concentration; SD, standard deviation; Tmax, time to maximum plasma concentration.
a
Reported by Ruan et al. (2014).
b
Median (range).