TABLE 2.
Meta-analysis results of adverse drug reactions (Supplementary Figures S25–S34).
| Indicators | Trials | Aidi injection with GP (Events/Total) | GP alone (Events/Total) | SM | Odds ratio, 95% CI | I2 | P |
|---|---|---|---|---|---|---|---|
| Myelosuppression (Supplementary Figure S25) | 17 | 218/642 | 342/632 | FEM | 0.36 [0.28, 0.47] | 31% | p < 0.00001 |
| Neutropenia (Supplementary Figure S26) | 40 | 626/1701 | 862/1670 | FEM | 0.41 [0.35, 0.49] | 0% | p < 0.00001 |
| Thrombocytopenia (Supplementary Figure S27) | 28 | 286/1181 | 409/1156 | FEM | 0.48 [0.39, 0.59] | 0% | p < 0.00001 |
| Anemia (Supplementary Figure S28) | 11 | 156/524 | 200/523 | FEM | 0.59 [0.43, 0.80] | 5% | p = 0.0009 |
| Gastrointestinal toxicity (Supplementary Figure S29) | 49 | 756/2043 | 1059/2002 | FEM | 0.45 [0.39, 0.51] | 0% | p < 0.00001 |
| Liver toxicity (Supplementary Figure S30) | 29 | 192/1284 | 285/1257 | FEM | 0.58 [0.47, 0.72] | 0% | p < 0.00001 |
| Renal toxicity (Supplementary Figure S31) | 24 | 132/1070 | 192/1044 | FEM | 0.62 [0.48, 0.79] | 0% | p = 0.0001 |
| Alopecia (Supplementary Figure S32) | 3 | 41/94 | 57/89 | REM | 0.27 [0.05, 1.37] | 70% | p = 0.11 |
| Neurotoxicity (Supplementary Figure S33) | 5 | 26/208 | 37/208 | FEM | 0.63 [0.35, 1.12] | 0% | p = 0.11 |
| Oral mucositis (Supplementary Figure S34) | 3 | 10/106 | 18/106 | FEM | 0.50 [0.22, 1.16] | 0% | p = 0.11 |
Note: GP: gemcitabine and cisplatin; SM: statistical method; REM: random-effects model; and FEM: fixed-effects model.