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. 2021 May 28;9:673838. doi: 10.3389/fcell.2021.673838

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Copyright © 2021 Sun, Wu, Yuan, Lu, Luo, Lin and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of CD8+ T-cell-associated immune-related genes (CDIRGs). (A) The landscape of UM single-cell samples; annotated UMAP plot identified a total of eight different cell types including B cells, CD4+ T cells, CD8+ T and T exhausted cells, endothelial, malignant, mono/macrophage, and plasma. (B) The pie plot of eight different cell types. Apart from malignant cells, CD8+ T exhausted cells take a larger component. (C) The bar plot for proportion of eight different cell types. (D) The volcano plot of the different expressed genes (DEGs) in CD8+ T cells. (E) The overlapped CDIRGs of DEGs and immune-related genes. (F) Gene Ontology (GO) enrichment analysis of the CDIRGs.