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. 2021 May 28;12:680043. doi: 10.3389/fphar.2021.680043

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Copyright © 2021 Shams, Martinez, Dawson, Flores, Gabriel, Garcia, Guevara, Murray, Pacifici, Vargas, Voelker, Hell and Ashouri.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MTX toxicity mechanism of action. Oligonucleotide synthesis is suppressed two-fold by MTXglu (methotrexate polyglutamate) via thymidylate synthase and dihydrofolate reductase inhibition.