TABLE 1.

FDA approved drugs to treat RA.

Name	Drug Type	Drug Class	Year Approved for RA	Molecular Weight	Chemical Structure	References
Methotrexate	Small molecule	Antimetabolite	1988	454.45 g/mol		Smolen et al. (2020); Malaviya (2016); Gubner et al. (1951); Wright et al. (1951); Rajagopalan et al. (2002); Hertz et al. (1956); Pannu (2019); Weinblatt et al. (1985); Tian and Cronstein (2007); Vega (2015); Brown et al. (2016); Wessels et al. (2008); Cronstein (2005); Yamamoto et al. (2016); Cronstein and Aune (2020); Nesher and Moore (1990); Nesher et al. (1996); Lawson et al. (2007); Chan and Cronstein (2010); Cronstein et al. (1991); Baggott et al. (1986); Cronstein et al. (1993); Morabito et al. (1998); Prabhakar et al.and (1995); Cronstein et al. (1986); Attar (2010); Hamid et al. (2018); Shiroky et al. (1993); Lindsay et al. (2009); Provenzano (2003); Albrecht and Müller-Ladner (2010); Bathon et al. (2000); Goekoop-Ruiterman et al. (2007); van Vollenhoven et al. (2009); Emery et al. (2012); Weinblatt et al. (1994); Singh et al. (2015); Breedveld et al. (2006); Heo et al. (2017); Matera et al. (2018)
Sulfasalazine	Compound molecule	Anti-inflammatory	1950	398.39 g/mol		Morabito et al. (1998); Choi and Fenando (2020); O'Dell (1998); Wahl et al. (1998); Cronstein et al. (1999); Park et al. (2019); Rodenburg et al. (2000); Lee et al. (2004); Hirohata et al. (2002); Volin et al. (2002); Suarez-Almazor et al. (2000b); O'Dell et al. (2002); Moreland et al. (2012); Curtis et al. (2020); Erhardt et al. (2019)
Hydroxychloroquine	Small molecule	Antimalarial	1956	433.95 g/mol		(Singh et al. (2015); O'Dell et al. (1996); Moreland et al. (2012); Administration USFD (2020); Schrezenmeier and Dorner (2020); Mok et al. (2005); Rempenault et al. (2018); Ruiz-Irastorza et al. (2009); Sharma et al. (2016); Tsakonas et al. (2000); Grigor et al. (2004); Circu et al. (2017); Mauthe et al. (2018); Wu et al. (2017); Rebecca et al. (2019); Ewald et al. (2008); Kuznik et al. (2011); Hjorton et al. (2018); Wallace et al. (1994); Wallace et al. (1993); Suarez-Almazor et al. (2000a); Koffeman et al. (2009); Ravindran and Alias (2017); Carmichael et al. (2002); Tett et al. (1989); Trnavský et al. (1993); Ma and Xu (2013)
Prednisone	Small molecule	Corticosteroid	2012	358.43 g/mol		van Everdingen et al. (2002); Wassenberg et al. (2005); Jacobs et al. (2006); Malysheva et al. (2008); Hafstrom et al. (2009); Pincus et al. (2009); Bakker et al. (2012); Krasselt and Baerwald (2014)
Tofacitinib	Small molecule	JAK inhibitor	2012	312.37 g/mol		Ghoreschi et al. (2011); Kwok (2014); Hodge et al. (2016); Schwartz et al. (2016); Keystone et al. (2017); Grigoropoulos et al. (2019); Itamiya et al. (2020)
Baricitinib	Small molecule	JAK inhibitor	2018	371.42 g/mol		(Ghoreschi et al., 2011; Keystone et al., 2017)
Upadacitinib	Small molecule	JAK inhibitor	2019	398.38 g/mol		Genovese et al. (2018); Parmentier et al. (2018); Brooks (2019)
Anakinra	Biologic	Interleukin antagonist	2001	17.3 kDa		Arend et al. (1990); Bresnihan et al. (1998); Cohen et al. (2002); Buch et al. (2004); Genovese et al. (2004); Mertens and Singh (2009a); Mertens and Singh (2009b); England et al. (2018)
Etanercept	Biologic	TNF inhibitor	1998	150 kDa	Humanized monoclonal antibody fragment fusion protein	Bathon et al. (2000); Genovese et al. (2004); Hetland et al. (2010); Emery et al. (2012); Moreland et al. (2012); Machado et al. (2013)
Abatacept	Biologic	TNF inhibitor	2005	92 kDa	Fully humanized monoclonal antibody	Kremer et al. (2006); Maxwell and Singh (2009); Blair and Deeks (2017)
Infliximab	Biologic	TNF inhibitor	1999	149.1 kDa	Chimeric (murine/human) monoclonal antibody	Lisman et al. (2002); Perdriger (2009); van Vollenhoven et al. (2009); Vermeire et al. (2009); Hetland et al. (2010); Monaco et al. (2015); Braun and Kay (2017); Scherlinger et al. (2017)
Adalimumab	Biologic	TNF inhibitor	2002	148 kDa	Fully humanized monoclonal antibody	Breedveld et al. (2006); Machado et al. (2013); Burmester et al. (2017); Keystone et al. (2017)
Golimumab	Biologic	TNF inhibitor	2009	150 kDa	Fully humanized monoclonal antibody	Braun and Kay (2017)
Certolizumab	Biologic	TNF inhibitor	2009	91 kDa	Humanized monoclonal antibody fragment conjugated to a PEG moiety	Kaushik and Moots (2005); Goel and Stephens (2010); Choy et al. (2012)
Tocilizumab	Biologic	IL-6 receptor inhibitor	2010	148 kDa	Humanized monoclonal antibody	Jones et al. (2010); Fleischmann et al. (2013); Kaneko (2013); Lee et al. (2014); Gale et al. (2019)
Sarilumab	Biologic	IL-6 receptor inhibitor	2017	150 kDa	Fully humanized monoclonal antibody	Tanaka and Martin Mola (2014); Burmester et al. (2017); McCarty and Robinson (2018)
Rituximab	Biologic	Anti-CD20	2006	145 kDa	Chimeric (murine/human) monoclonal antibody	Reff et al. (1994); Anderson et al. (1997); Clynes et al. (2000); Edwards and Cambridge (2001); Shaw et al. (2003); Edwards et al. (2004); Weiner (2010); Keystone et al. (2012)