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. 2021 May 31;12:649604. doi: 10.3389/fphys.2021.649604

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Copyright © 2021 Masso-Silva, Moshensky, Shin, Olay, Nilaad, Advani, Bojanowski, Crotty, Li, Ongkeko, Singla and Crotty Alexander.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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JUUL Mint aerosol inhalation drives upregulation of ACE2 expression within the lungs. Relative gene expression by qPCR from lung tissues of mice exposed for 1 h daily to e-cig aerosols was analyzed. Male C57BL/6 mice were exposed to nicotine containing (Ecig) and no nicotine (Vehicle) e-cig aerosols generated by box Mods (70:30 PG:VG with 6 mg/mL nicotine) for 3 months, with no significant differences found relative to Air controls. Female C57BL/6 mice exposed for 20 min three times daily for 1 month to aerosols generated from JUUL (30:70 PG:Gly with 59 mg/mL nicotine) Mint flavored pods had three-fold greater ACE2 expression in the lung, while chronic JUUL Mango aerosol inhalation did not alter ACE2 expression. ****p < 0.0001. Data are representative of five mice per group.