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. 2021 May 28;12:685473. doi: 10.3389/fphys.2021.685473

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Copyright © 2021 Möstl, Orter, Hoffmann, Bachler, Hametner, Wassertheurer, Rabineau, Mulder, Johannes, Jordan and Tank.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exploratory analysis relating the HDTBR response to age. We stratified participants in three age groups (AgeGr.): AgeGr. 1 = 24–27 years; AgeGr. 2 = 29–36 years, and AgeGr. 3 = 37–55 years. (A) heart rate, (B) systolic blood pressure (SBP), (C) aortic compliance (AOC), and corrected pulse wave arrival times to the (D) arm (cPAT_Arm), (E) thigh (cPAT_Thigh), and (F) finger (cPAT_Finger). The p-values indicate the interaction between AgeGr. and bed rest. Results are represented as mean values ± standard deviation from base line recordings (PRE, dot symbol) and HDT (square symbol). Significant difference between these time points is indicated by ^†(p < 0.05) and ‡(p < 0.001).