Table 5.

Classification of the Publications into Several Groups According to the Bioassays Related to the Selected Targets

category	$N_{\text{tr}}^{\text{pos}}$a	$N_{\text{tr}}^{\text{neg}}$b	$N_{\text{test}}^{\text{pos}}$c	$N_{\text{test}}^{\text{neg}}$d	Sens	Spec	BA
target	carbonic anhydrase II (human)
cell-based/pH shift/colorimetric assay	24	94	20	78	0.79	0.96	0.88
cell-based/human/spectro-photometrical assay under 400 nm	68	50	31	67	0.81	0.69	0.75
cell-based/miscellaneous/spectro-photometrical assay 400 nm and above	14	104	20	78	0.54	0.78	0.66
cell-based/other methods	12	106	27	71	0.42	0.95	0.69
target	cyclooxygenase 2 (human)
cell-based/human/radio immuno-assay	14	102	11	108	0.61	0.94	0.78
cell-based/human/enzyme immuno-assay	11	105	12	107	0.89	0.74	0.82
cell-based/other detection methods	89	27	94	25	0.88	0.63.	0.76
target	cytochrome p450 3A4 (Cyp 3A4 human)
Cyp 3A4-based conversion/testosterone/HPLC	21	68	24	54	0.69	0.97	0.83
Cyp 3A4-based conversion/unknown substrate/LC–MS	51	38	34	44	0.74	0.65	0.70
Cyp 3A4 activity/luminescence	13	76	18	50	0.79	0.96	0.88
Cyp 3A4 expression	4	85	2	76	N/De	N/D	N/D
target	vascular endothelial growth factor 2 (human)
fluorescence/kinase-activated fluorescent peptides/human umbilical cells	34	79	38	113	0.65	0.84	0.75
cell-based/ELISA	11	102	10	141	0.78	0.84	0.81
other methods	21	92	24	127	0.46	0.68	0.57

^a$N_{\text{tr}}^{\text{pos}}$ is the number of positive samples (fragments belonging to the particular category) in the training set.

^b$N_{\text{tr}}^{\text{neg}}$ is the number of negative samples (fragments not belonging to the particular category) in the training set.

^c$N_{\text{test}}^{\text{pos}}$ is the number of positive samples in the test set.

^d$N_{\text{test}}^{\text{neg}}$ is the number of negative samples in the test set.

^eN/D: not enough data to build a model.