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. Author manuscript; available in PMC: 2022 May 13.
Published in final edited form as: J Med Chem. 2021 May 5;64(9):6262–6272. doi: 10.1021/acs.jmedchem.1c00296

Figure 4.

Figure 4.

Inhibition of Mtb20S by macrocycle 6. A) Structure of macrocycle 6. B) Time-dependent inhibition of Mtb20S by macrocycle 6 at indicated concentration C) Plot of kobs vs concentration of macrocycle 6 yielded k3 of 5.7 × 104 s−1M−1 and k4 of 0.7 × 10−3 s−1.