TABLE 3.
Multivariate Cox proportional hazards regression analysis of NLR and PLR with overall survival.
| Characteristic | B | SE B | Wald | HR | 95% CI | p value | |
|---|---|---|---|---|---|---|---|
| NLR | |||||||
| Tumor size (cm) | >5/≤5 | 0.344 | 0.136 | 6.434 | 1.410 | 1.081–1.840 | 0.011 |
| PVTT | Yes/no | 0.466 | 0.141 | 10.950 | 1.593 | 1.209–2.099 | 0.001 |
| Extrahepatic spread | Yes/no | 0.708 | 0.202 | 12.229 | 2.029 | 1.365–3.017 | <0.001 |
| NLR | ≥2.42/<2.42 | 0.305 | 0.131 | 5.4333 | 1.356 | 1.050–1.753 | 0.020 |
| PLR | |||||||
| PVTT | Yes/no | 0.487 | 0.140 | 12.133 | 1.627 | 1.237–2.139 | <0.001 |
| Extrahepatic spread | Yes/no | 0.915 | 0.197 | 21.544 | 2.497 | 1.697–3.674 | <0.001 |
| AST | >40/≤40 | 0.298 | 0.129 | 5.368 | 1.348 | 1.047–1.735 | 0.021 |
| PLR | ≥100/<100 | 0.366 | 0.128 | 8.120 | 1.442 | 1.121–1.855 | 0.004 |
AST, aspartate transaminase; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; PVTT, portal vein tumor thrombus; SE, standard error; CI, confidence interval; HR, hazard ratio.