Table 3.
Logistic regression analysis of risk factors for hyperthyroidism and Graves’ disease.
| Parameters | Mild subclinical hyperthyroidism | Severe subclinical hyperthyroidism | Overt hyperthyroidism | Graves’ disease | |||||
|---|---|---|---|---|---|---|---|---|---|
| OR(95%CI) | P | OR(95%CI) | P | OR(95%CI) | P | OR(95%CI) | P | ||
| Model1 a | |||||||||
| Gender | Male | 1.00(reference) | 1.00(reference) | 1.00(reference) | 1.00(reference) | ||||
| Female | 1.50(1.10-2.04) | 0.010 | 2.53(1.81-3.53) | 0.000 | 1.70(1.44-2.01) | 0.000 | 1.79(1.46-2.20) | 0.000 | |
| Age | 18-29 | 1.00(reference) | 1.00(reference) | 1.00(reference) | 1.00(reference) | ||||
| 30-39 | 1.63(0.93-2.87) | 0.087 | 0.94(0.59-1.49) | 0.782 | 1.08(0.85-1.37) | 0.540 | 1.15(0.86-1.54) | 0.352 | |
| 40-49 | 1.89(1.10-3.22) | 0.021 | 1.11(0.72-1.72) | 0.627 | 1.06(0.84-1.35) | 0.604 | 1.15(0.87-1.54) | 0.327 | |
| 50-59 | 2.99(1.78-5.03) | 0.000 | 1.12(0.70-1.78) | 0.647 | 1.07(0.83-1.38) | 0.583 | 1.17(0.86-1.59) | 0.312 | |
| ≥60 | 2.61(1.54-4.43) | 0.000 | 0.95(0.59-1.54) | 0.843 | 0.75(0.57-0.99) | 0.040 | 0.77(0.55-1.09) | 0.139 | |
| Ethnicity | Han | 1.00(reference) | 1.00(reference) | 1.00(reference) | 1.00(reference) | ||||
| Tibet | 1.68(0.82-3.45) | 0.153 | 0.34(0.08-1.36) | 0.126 | 0.36(0.17-0.75) | 0.007 | 0.22(0.07-0.69) | 0.009 | |
| Uygur | 4.41(2.69-7.24) | 0.000 | 1.81(0.92-3.56) | 0.084 | 1.12(0.71-1.77) | 0.637 | 0.85(0.45-1.60) | 0.616 | |
| Hui | 0.97(0.31-3.04) | 0.954 | 1.10(0.41-2.98) | 0.847 | 0.97(0.54-1.72) | 0.909 | 0.59(0.24-1.42) | 0.237 | |
| Zhuang | 2.92(1.57-5.41) | 0.001 | 1.31(0.58-2.96) | 0.520 | 1.65(1.11-2.46) | 0.013 | 2.32(1.55-3.50) | 0.000 | |
| Model2 b | |||||||||
| Gender | Male | 1.00(reference) | 1.00(reference) | 1.00(reference) | 1.00(reference) | ||||
| Female | 1.46(0.99-2.15) | 0.057 | 2.06(1.34-3.16) | 0.001 | 1.03(0.83-1.28) | 0.781 | 0.99(0.76-1.30) | 0.961 | |
| Age | 18-29 | 1.00(reference) | 1.00(reference) | 1.00(reference) | 1.00(reference) | ||||
| 30-39 | 1.68(0.95-2.98) | 0.075 | 0.94(0.59-1.50) | 0.782 | 0.98(0.77-1.25) | 0.851 | 0.94(0.69-1.27) | 0.673 | |
| 40-49 | 1.85(1.07-3.21) | 0.028 | 1.055(0.68-1.64) | 0.814 | 0.90(0.71-1.16) | 0.851 | 0.84(0.63-1.13) | 0.257 | |
| 50-59 | 2.71(1.57-5.16) | 0.000 | 1.12(0.70-1.80) | 0.630 | 0.91(0.70-1.19) | 0.504 | 0.83(0.60-1.14) | 0.241 | |
| ≥60 | 2.71(1.58-4.66) | 0.000 | 0.97(0.60-1.59) | 0.916 | 0.68(0.51-0.90) | 0.008 | 0.58(0.41-0.82) | 0.002 | |
| Ethnicity | Han | 1.00(reference) | 1.00(reference) | 1.00(reference) | 1.00(reference) | ||||
| Tibet | 1.97(0.96-4.06) | 0.065 | 0.49(0.12-1.96) | 0.310 | 0.48(0.21-1.07) | 0.074 | 0.33(0.11-1.03) | 0.057 | |
| Uygur | 4.58(2.78-7.54) | 0.000 | 2.02(1.03-4.00) | 0.055 | 1.23(0.77-1.96) | 0.390 | 0.83(0.44-1.59) | 0.577 | |
| Hui | 1.02(0.32-3.21) | 0.975 | 1.19(0.44-3.22) | 0.737 | 1.24(0.69-2.21) | 0.478 | 0.90(0.37-2.19) | 0.808 | |
| Zhuang | 2.89(1.55-5.39) | 0.001 | 1.35(0.59-3.07) | 0.475 | 1.49(0.99-2.23) | 0.057 | 1.81(1.18-2.76) | 0.006 | |
| UIC | <100 | 1.02(0.67-1.55) | 0.926 | 0.64(0.38-1.08) | 0.639 | 1.35(1.07-1.72) | 0.013 | 1.67(1.30-2.15) | 0.000 |
| 100-199 | 1.00(reference) | 1.00(reference) | 1.00(reference) | 1.00(reference) | |||||
| 200-299 | 1.03(0.69-1.56) | 0.876 | 1.32(0.89-1.96) | 0.164 | 1.12(0.88-1.43) | 0.355 | 1.02(0.77-1.36) | 0.873 | |
| ≥300 | 1.37(0.90-2.08) | 0.138 | 1.90(1.30-2.79) | 0.001 | 2.09(1.68-2.59) | 0.000 | 1.05(0.78-1.42) | 0.748 | |
| Antibody | TPOAb | 1.97(1.27-3.07) | 0.003 | 3.01(2.00-4.53) | 0.000 | 6.94(5.56-8.67) | 0.000 | 18.93(14.41-24.86) | 0.082 |
| TGAb | 1.41(0.89-2.25) | 0.134 | 2.22(1.47-3.37) | 0.000 | 2.36(1.90-2.95) | 0.000 | 1.61(1.27-2.05) | 0.000 | |
| History | Family | 1.33(0.78-2.28) | 0.506 | 1.33(0.81-2.19) | 0.257 | 1.75(1.37-2.24) | 0.000 | 1.78(1.35-2.35) | 0.000 |
| Smoking | Yes | 1.23(0.79-1.90) | 0.359 | 1.13(0.69-1.85) | 0.625 | 1.12(0.88-1.44) | 0.356 | 1.31(0.97-1.77) | 0.082 |
| Model3 c | |||||||||
| TPOAb | <15 | 1.00(reference) | 1.00(reference) | 1.00(reference) | 1.00(reference) | ||||
| 15-34 | 1.04(0.67-1.62) | 0.847 | 1.50(0.96-2.35) | 0.073 | 1.27(0.93-1.72) | 0.127 | 2.61(1.41-3.32) | 0.000 | |
| 35-60 | 1.39(0.59-3.29) | 0.455 | 1.77(0.78-4.02) | 0.174 | 3.17(2.07-4.87) | 0.000 | 10.83(6.55-17.92) | 0.000 | |
| 61-115 | 0.92(0.32-2.62) | 0.873 | 2.97(1.50-5.90) | 0.002 | 5.49(3.78-7.97) | 0.000 | 21.00(13.33-33.07) | 0.000 | |
| 116-200 | 1.97(0.88-4.41) | 0.098 | 1.93(0.86-4.32) | 0.110 | 5.06(3.44-7.46) | 0.000 | 20.09(13.33-33.07) | 0.000 | |
| 201-400 | 1.91(.92-3.98) | 0.082 | 3.69(2.03-6.69) | 0.000 | 6.60(4.70-9.27) | 0.000 | 33.06(21.62-50.54) | 0.000 | |
| >400 | 1.97(0.94-4.14) | 0.073 | 2.87(1.49-5.53) | 0.002 | 8.13(5.80-11.40) | 0.000 | 36.92(23.87-57.12) | 0.000 | |
| TgAb | <15 | 1.00(reference) | 1.00(reference) | ||||||
| 15-34 | 1.49(1.02-2.18) | 0.038 | 1.56(1.01-2.41) | 0.043 | 1.62(1.24-2.13) | 0.000 | 1.40(0.97-2.02) | 0.070 | |
| 35-60 | 1.4(0.58-3.38) | 0.457 | 1.25(0.47-3.310 | 0.649 | 2.11(1.33-3.36) | 0.002 | 0.95(0.52-1.70) | 0.852 | |
| 61-115 | 2.21(1.08-4.50) | 0.029 | 2.77(1.38-5.57) | 0.004 | 2.48(1.62-3.78) | 0.000 | 1.19(0.71-2.00) | 0.514 | |
| 116-200 | 1.06(0.37-3.07) | 0.915 | 2.42(1.10-5.35) | 0.029 | 2.51(1.60-3.94) | 0.000 | 1.34(0.79-2.28) | 0.283 | |
| 201-400 | 1.46(0.68-3.13) | 0.332 | 3.45(1.87-6.39) | 0.000 | 3.07(2.11-4.46) | 0.000 | 1.27(0.80-2.04) | 0.312 | |
| >400 | 2.85(1.49-5.43) | 0.002 | 3.52(1.89-6.54) | 0.000 | 4.51(3.16-6.43) | 0.000 | 1.8(1.16-2.81) | 0.009 | |
a
Model 1 adjusted for gender, age and ethnicity.
b
Model 2 adjusted for gender, age, ethnicity, UIC, antibody, family history, and smoking.
c
Model 3 adjusted for gender, age, ethnicity, UIC, antibody(delimitation by titer), family history, and smoking.
CI, Confidence interval; OR, odds ratio; TgAb, thyroglobulin antibody; TPOAb, thyroid peroxidase antibody; UIC, urinary iodine concentration.
Values in bold indicate P < 0.05.