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. 2020 Dec 7;320(1):E150–E159. doi: 10.1152/ajpendo.00161.2020

Figure 1.

Figure 1.

Myostatin deficiency improved survival (A), ameliorated body weight loss (B), and mitigated bacterial loads (C) after cecum ligation and puncture (CLP) in mice. A: survival was improved in myostatin-deficient (MSTN) mice (n = 19) compared with age- and body weight (BW)-matched wild-type (WT) mice (n = 8 and 23 per group, respectively). ****P < 0.0001. B: body weight loss was ameliorated in myostatin-deficient (MSTN) mice (n = 18) compared with body weight-matched wild-type (WT) mice (n = 8). *P < 0.05, **P < 0.01 vs. WT mice. C: bacterial loads in the circulation and peritoneal cavity were significantly lower in myostatin-deficient (MSTN) mice (n = 7) than body weight-matched wild-type (WT) mice (n = 8). ***P < 0.001, ****P < 0.0001 vs. WT mice.