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. 2020 Dec 7;320(1):E150–E159. doi: 10.1152/ajpendo.00161.2020

Figure 4.

Figure 4.

Effects of myostatin deficiency on sepsis-induced expression of MuRF-1 and atrogin-1 and phosphorylation of STAT3 in mouse skeletal muscle. Myostatin deficiency (MSTN) inhibited cecum ligation and puncture (CLP)-induced increases in expression of MuRF-1 and atrogin-1 and phosphorylation of STAT3 in gastrocnemius muscle compared with body weight-matched wild-type (WT) mice. **P < 0.01, ***P < 0.001 vs. WT mice without CLP, †P < 0.05, ††P < 0.01 vs. WT mice with CLP. WT mice without CLP: n = 3, WT mice with CLP: n = 6, MSTN mice without CLP: n = 3, MSTN mice with CLP: n = 6. MuRF-1, muscle-specific RING finger protein 1; STAT3, signal transducer and activator of transcription protein 3.