Table 2.

Evaluating mutual changes in secretion and sensitivity

Multivariate Tests
Within-subjects effect	Measure	IGI with IFI	iAUC Ratio with IFI	Phase 1 with M/I	Phase 2 with M/I
Time	Joint secretion and sensitivity	0.012	0.010	0.009	0.038
Time × Group	Joint secretion and sensitivity	0.708	0.309	0.670	0.888
Post Hoc Univariate Tests
Source	Measure	IGI with IFI	iAUC with IFI	Phase 1 with M/I	Phase 2 with M/I
Time	Secretion	0.169	0.247	0.718	0.159
Sensitivity	0.003	0.004	0.034	0.024
Time × Group	Secretion	0.889	0.166	0.487	0.804
Sensitivity	0.408	0.518	0.973	0.985

Values in cells are P values. Evaluations were performed using log-transformed secretion and sensitivity terms as described in methods. Analyses used multivariate methodology to first compare the simultaneous changes in secretion and sensitivity (top) and post hoc univariate testing to isolate the source of significant change (bottom table). In each instance, a Time × Group interaction term was evaluated to determine whether observed effects differed by randomized treatment group. Values achieving statistical significance are presented in boldface. iAUC ratio, incremental area under the curve for insulin divided by incremental area under the curve for glucose; IGI, insulinogenic index; IFI, inverse fasting insulin; M/I, clamp steady-state glucose disposal rate divided by steady-state insulin concentrations. Statistically significant values are presented in bold for convenience.