Table 3.

Evaluating changes in secretion-sensitivity relationships using new and traditional methods

	Intercept		Slope		DI
	Time	Group * Time	Time	Group * Time	Time	Group * Time
IGI with IFI	0.044	0.503	0.022	0.674	0.259	0.227
iAUC ratio with IFI	0.025	0.357	0.010	0.581	0.158	0.159
Phase 1 with M/I	0.025	0.037	<0.001	0.047	<0.001	0.599
Phase 2 with M/I	0.169	0.095	0.432	0.086	0.003	0.982

Values in cells are P values. Evaluations were performed using log-transformed secretion and sensitivity terms and repeated-measures mixed modeling as described in methods. In each instance, a Group × Time interaction term was evaluated to determine whether observed effects differed by time and/or study treatment. Values achieving statistical significance are presented in boldface. DI, disposition index; iAUC ratio, incremental area under the curve for insulin divided by incremental area under the curve for glucose; IGI, insulinogenic index; IFI, inverse fasting insulin; M/I, clamp steady-state glucose disposal rate divided by steady-state insulin concentrations. Statistically significant values are presented in bold for convenience.