Table 1.
All (51) | Male (17) | Female (34) | |
---|---|---|---|
Age, yr | 54.4 ± 12.7 | 52.4 ± 14.9 | 55.4 ± 11.5 |
Total body mass, kg | 81.9 ± 15.3 | 91.0 ± 13.0 | 77.3 ± 14.4 |
Lean body mass, kg | 47.5 ± 10.4 | 59.6 ± 3.4 | 41.5 ± 5.5 |
Height, cm | 170.1 ± 9.8 | 179.5 ± 6.2 | 165.4 ± 7.7 |
BMI, kg/m2 | 28.2 ± 3.9 | 28.2 ± 3.4 | 28.1 ± 4.1 |
BSA, m2 | 1.9 ± 0.2 | 2.1 ± 0.2 | 1.8 ± 0.2 |
Exponential Parametrization | |||
A1, L−1 | 0.14 ± 0.04 | 0.12 ± 0.03 | 0.15 ± 0.05 |
α1, min−1 | 0.19 ± 0.05 | 0.20 ± 0.06 | 0.19 ± 0.05 |
Kinetic parameters | |||
Volume, L | 8.18 ± 2.68 | 9.23 ± 2.45 | 7.65 ± 2.67 |
t1/2, min | 3.96 ± 1.12 | 4.01 ± 1.19 | 3.94 ± 1.10 |
CL, L/min | 1.44 ± 0.33 | 1.64 ± 0.36 | 1.34 ± 0.27 |
Vol/TBM, L/kg | 0.10 ± 0.03 | 0.12 ± 0.03 | 0.10 ± 0.03 |
Data reported as means ± SD. BMI, body mass index; BSA, body surface area; CL, clearance rate; TBM, total body mass.