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. 2021 May 28;12:631282. doi: 10.3389/fmicb.2021.631282

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Copyright © 2021 Ioannou, Knol and Belzer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GH profiles per phylum and feeding in (A) newborns, (B) 4-month-old infants, and (C) 12-month-old infants. GHs were detected in MAGs of Nayfach et al. (2019) derived from the original dataset of Bäckhed et al. (2015). The identification method was based on domain-based Hidden Markov Models against the dbCAN CAZyme domain HMM database (Lombard et al., 2014; Zhang et al., 2018). GHs are grouped into: (blue) HMO-related, (red) HMO- and GOS-related, (green) GOS-related, (yellow) FOS-related. Presence of the GH family is signified with a black box and abscence with a white box.