Table 3.
Percentage of Intubated Patients With COVID-19 Who Received Drug Doses Exceeding Recommended Rangea,b
| Propofol | DEX | Midazolam | Ketamine | Fentanyl | HYDRO | |
|---|---|---|---|---|---|---|
| Day 1 | 16 (18.60) | 2 (2.33) | 1 (1.16) | 1 (1.16) | 0 (0) | 0 (0) |
| Day 2 | 41 (47.67) | 6 (6.98) | 1 (1.16) | 7 (8.14) | 0 (0) | 9 (10.47) |
| Day 3 | 27 (31.40) | 11 (12.79) | 1 (1.16) | 13 (15.12) | 0 (0) | 17 (19.77) |
| Day 4 | 19 (22.35) | 21 (24.71) | 5 (5.88) | 16 (18.82) | 0 (0) | 17 (20.00) |
| Day 5 | 23 (27.38) | 20 (23.81) | 4 (4.76) | 23 (27.38) | 0 (0) | 18 (21.43) |
| Day 6 | 19 (23.17) | 17 (20.73) | 5 (6.10) | 24 (29.27) | 0 (0) | 21 (25.61) |
| Day 7 | 18 (23.08) | 18 (23.08) | 6 (7.69) | 22 (28.21) | 0 (0) | 26 (33.33) |
| Day 8 | 18 (24.66) | 19 (26.03) | 4 (5.48) | 21 (28.77) | 0 (0) | 25 (34.25) |
| Day 9 | 17 (25.00) | 20 (29.41) | 4 (5.88) | 22 (32.35) | 0 (0) | 26 (38.24) |
| Day 10 | 20 (30.30) | 18 (27.27) | 3 (4.55) | 17 (25.76) | 0 (0) | 25 (37.88) |
Abbreviations: DEX, dexmedetomidine; HYDRO, hydromorphone.
aAll data are number (percentage) of patients; the denominator (n) for percentage calculations varied from?? to 86. To allow for more precise comparisons, percentages were not rounded.
bAs per 2013 Society of Critical Care (SCCM) clinical practice guidelines,8 recommended dose ranges are as follows: propofol, 5-50 µg/kg/min; dexmedetomidine, 0.2-0.7 µg/kg/h; midazolam, 0.02-0.10 mg/kg/h; ketamine, 0.05-0.4 mg/kg/h; fentanyl, 0.7-10 µg/kg/h; and hydromorphone, 0.5-3.0 mg/h.