TABLE 3.

Cox regression models for primary and secondary outcomes according to 25(OH)D categories in patients with moderate to severe COVID-19¹

	Number of events	Unadjusted			Adjusted2
25(OH)D (ng/mL)		HR	(95% CI)	P	HR	(95% CI)	P
Hospital discharge3
Model 1
<10	15	Ref			Ref
10 to <20	96	1.64	(0.92, 2.91)	0.092	1.58	(0.86, 2.91)	0.142
20 to <30	67	1.35	(0.76, 2.41)	0.312	1.45	(0.78, 2.71)	0.242
≥30	28	1.45	(0.76, 2.80)	0.263	1.33	(0.66, 2.67)	0.433
Model 2
<10	15	Ref			Ref
≥10	191	1.48	(0.85, 2.57)	0.162	1.50	(0.83, 2.70)	0.181
Mechanical ventilation
Model 1
<10	1	Ref			Ref
10 to <20	7	0.72	(0.06, 8.26)	0.790	0.36	(0.02, 6.33)	0.482
20 to <30	11	1.96	(0.20, 19.24)	0.564	2.56	(0.19, 34.39)	0.480
≥30	3	2.49	(0.21, 28.99)	0.467	3.40	(0.21, 55.65)	0.391
Model 2
<10	1	Ref			Ref
≥10	21	1.60	(0.17, 15.24)	0.684	1.45	(0.12, 17.51)	0.768
Mortality
Model 1
<10	1	Ref			Ref
10 to <20	1	0.27	(0.02, 4.93)	0.378	*
20 to <30	4	0.99	(0.10, 9.70)	0.990	*
≥30	2	1.47	(0.11, 19.04)	0.775	*
Model 2
<10	1	Ref			Ref
≥10	7	0.77	(0.08, 7.38)	0.824	*

*There were not enough cases to estimate after stratification by center and adjustment for possible confounders.

¹All analyses were stratified by center. COVID-19, coronavirus disease 2019; Ref, reference; 25(OH)D, 25-hydroxyvitamin D.

²Multivariable Cox regression adjusted for age, sex, race, BMI, cardiovascular disease, and chronic obstructive pulmonary disease.

³Hospital discharge refers to the number of surviving patients (death censored).