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Karyopherins abnormalities in neurodegenerative proteinopathies. Left: In ALS/FTD-TDP, cytoplasmic accumulation of TDP-43 and its aggregates not associated with stress granules have been shown to sequester KPNAs. Right: In Alzheimer’s disease and FTD-Tau, pathological tau has been shown to sequester KPNAs (Table 3). AD = Alzheimer’s disease; CAS = cellular apoptosis susceptibility.
