Table 1.
KPNA proteins and their essential cargos
| Gene/Protein name | NCBI ID | Subfamily | Synonyms |
Cargos | References | |||
|---|---|---|---|---|---|---|---|---|
| Importin | SRP | NPI/QIP | Other | |||||
| KPNA1 | 3836 | α3 | IPOA-5 | SRP1β | NPI-1 | RCH2 | TDP-43 NF-κB (p50/p65; c-Rel; p52; RelB) | Pumroy and Cingolani,27 Lee et al.,50 Nishimura et al.54 |
| KPNA2 | 3838 | α1 | IPOA-1 | SRP1α | NPI-3 | RCH1 | TDP-43 NF-κB (p65) | Pumroy and Cingolani,27 Nishimura et al.54 |
| KPNA3 | 3839 | α2 | IPOA-4 | SRP4, hSRP1, SRP1γ | QIP2 | n/a | TDP-43a NF-κB (p50/p65; p52) ataxin-3 α1ACT | Pumroy and Cingolani,27 Nishimura et al.,54 Khsoravi et al.,208 Sowa et al.,209 Tsou et al.,210 Fagerlund et al.211 |
| KPNA4 | 3840 | α2 | IPOA-3 | SRP3 | QIP1 | MGC12217 | TDP-43a NF-κB (p50/p65; p52) | Pumroy and Cingolani,27 Nishimura et al.54 Khosravi et al.,208 Fagerlund et al.211 |
| KPNA5 | 3841 | α3 | IPOA-6 | SRP6 | n/a | n/a | TDP-43 NF-κB (p50/p65; c-Rel; p52; RelB) | Pumroy and Cingolani,27 Nishimura et al.54 |
| KPNA6 | 23633 | α3 | IPOA-7 | n/a | NPI-2 | MGC17918 | TDP-43 NF-κB (c-Rel; RelB) | Pumroy and Cingolani.,27 Nishimura et al.54 |
| KPNA7 | 402569 | α1 | IPOA-8 | n/a | n/a | n/a | n/a | n/a |
IPOA = importin alpha; MGC = Mammalian Gene Collection; n/a = not applicable; NF-κB = nuclear factor-κB; NPI = nucleoprotein interactor; QIP = Importin alpha Q; RCH = RAG cohort protein; SRP = signal recognition particle.
a
Whilst TDP-43 acts as a cargo for KPNA1–6, KPNA3 and 4 show the strongest interactions.