FIGURE 4.

The metabolic pathways most altered in patients with PANS diagnosis were histidine metabolism, phenylalanine, tyrosine and tryptophan metabolism, tyrosine metabolism, glutathione metabolism, glycine, serine and threonine metabolism, alanine, aspartate and glutamate metabolism, glutamine and glutamate metabolism. (A) The size of the circles represent the pathway impact while the colors (varying from yellow to red) reflect the different levels of significance. (B) Also the enrichment analysis performed with the same software, confirm the same altered metabolic nets.