TABLE 3.
Comparison on 67 biomarkers between dMCAo + vehicle and dMCAo + VPA groups.
| Biomarker | dMCAo + VPA | dMCAo + vehicle | FoldChange | statistic | p.value | FDR | entrez_id |
| Galectin-3 | 4.01(3.2, 6.18) | 15.43(5.14, 15.77) | 3.850125136 | Wilcoxon W = 2 | 0.003175 | 0.031042 | 83781 |
| Adiponectin | 2.21 ± 1.92 | 7.46 ± 3.27 | 3.368981525 | t = –3.0969 | 0.019277 | 0.531042 | 246253 |
| IL-1 ra | 0(0, 0) | 21.98(0, 75.63) | 2198.554233 | Wilcoxon W = 2.5 | 0.02537 | 0.531042 | 60582 |
| IL-6 | 7.52(0, 22.56) | 0(0, 1.73) | 0.001327755 | Wilcoxon W = 22 | 0.044909 | 0.531042 | 24498 |
| FGF-BP | 301.74 ± 135.3 | 460.75 ± 66.35 | 1.526962995 | t = –2.3594 | 0.057642 | 0.531042 | 64535 |
| IL-1 R6 | 225.24(0, 3432.54) | 0(0, 0) | 4.44E-05 | Wilcoxon W = 20 | 0.072006 | 0.531042 | 171106 |
| P-Cadherin | 0(0, 0) | 10.43(0, 22.32) | 1044.471407 | Wilcoxon W = 5 | 0.072006 | 0.531042 | 116777 |
| TREM-1 | 0(0, 0) | 4.49(0, 10.61) | 449.8794155 | Wilcoxon W = 5 | 0.072006 | 0.531042 | 301229 |
| SCF | 3.77 ± 2.71 | 11.03 ± 7.76 | 2.928412671 | t = –1.976 | 0.105526 | 0.623708 | 60427 |
| JAM-A | 7.58 ± 7.42 | 16.97 ± 9.35 | 2.237719561 | t = –1.7577 | 0.118792 | 0.623708 | 116479 |
| IL-2 R alpha | 0(0, 1.8) | 1.21(0, 43.35) | 121.5922312 | Wilcoxon W = 5 | 0.118797 | 0.623708 | 25704 |
| HGF | 26.28(0, 48.32) | 132.12(0, 180.73) | 5.026618741 | Wilcoxon W = 5 | 0.138792 | 0.623708 | 24446 |
| Erythropoietin | 0(0, 173.89) | 67(0, 257.54) | 6700.768421 | Wilcoxon W = 5.5 | 0.161238 | 0.623708 | 24335 |
| CD48 | 0(0, 0) | 0(0, 13.61) | 1 | Wilcoxon W = 7.5 | 0.179712 | 0.623708 | 245962 |
| CINC-2 | 0(0, 1.29) | 0(0, 0) | 1 | Wilcoxon W = 17.5 | 0.179712 | 0.623708 | 171551 |
| gp130 | 0(0, 0) | 0(0, 204.37) | 1 | Wilcoxon W = 7.5 | 0.179712 | 0.623708 | 25205 |
| RAGE | 0(0, 93.74) | 0(0, 0) | 1 | Wilcoxon W = 17.5 | 0.179712 | 0.623708 | 81722 |
| Neuropilin-1 | 916.22 ± 718.22 | 1491.07 ± 633.66 | 1.627402803 | t = –1.342 | 0.216978 | 0.690058 | 246331 |
| Prolactin | 49.11(2.2, 104.24) | 67.37(45.9, 234.69) | 1.371723009 | Wilcoxon W = 6 | 0.222222 | 0.690058 | 24683 |
| Prolactin R | 0(0, 394.66) | 199.46(0, 860.2) | 19946.8758 | Wilcoxon W = 6.5 | 0.235861 | 0.695791 | 24684 |
| CTACK | 42601.63 ± 25019.88 | 60571.41 ± 20800.69 | 1.421809662 | t = –1.2349 | 0.253013 | 0.706855 | 362505 |
| CNTF | 5.56 ± 6.14 | 10.8 ± 7.51 | 1.940993959 | t = –1.206 | 0.263573 | 0.706855 | 25707 |
| TIMP-1 | 1297.87 ± 1033.13 | 2371.34 ± 1771.85 | 1.827096283 | t = –1.1703 | 0.283371 | 0.726908 | 116510 |
| Notch-2 | 571.4(523.82, 1436.6) | 744.09(542.62, 1286.46) | 1.30221903 | Wilcoxon W = 7 | 0.309524 | 0.742871 | 29492 |
| Activin A | 0(0, 0) | 0(0, 560.91) | 1 | Wilcoxon W = 10 | 0.423711 | 0.742871 | 29200 |
| b-NGF | 0(0, 0) | 0(0, 11.38) | 1 | Wilcoxon W = 10 | 0.423711 | 0.742871 | 310738 |
| CINC-3 | 0(0, 0) | 0(0, 0.85) | 1 | Wilcoxon W = 10 | 0.423711 | 0.742871 | 114105 |
| EphA5 | 0(0, 0) | 0(0, 58.11) | 1 | Wilcoxon W = 10 | 0.423711 | 0.742871 | 79208 |
| IFNg | 0(0, 0) | 0(0, 0.03) | 1 | Wilcoxon W = 10 | 0.423711 | 0.742871 | 25712 |
| IL-13 | 0(0, 1.14) | 0(0, 0) | 1 | Wilcoxon W = 15 | 0.423711 | 0.742871 | 116553 |
| LIX | 0(0, 0.28) | 0(0, 0) | 1 | Wilcoxon W = 15 | 0.423711 | 0.742871 | 60665 |
| RANTES | 0(0, 0) | 0(0, 0.13) | 1 | Wilcoxon W = 10 | 0.423711 | 0.742871 | 81780 |
| TIMP-2 | 0(0, 0) | 0(0, 2.41) | 1 | Wilcoxon W = 10 | 0.423711 | 0.742871 | 29543 |
| CINC-1 | 0(0, 6.32) | 0(0, 2.52) | 1 | Wilcoxon W = 16 | 0.440686 | 0.742871 | 81503 |
| MIP-1 alpha | 0(0, 368.16) | 0(0, 62.21) | 1 | Wilcoxon W = 16 | 0.440686 | 0.742871 | 25542 |
| Gas 1 | 26.56 ± 18.14 | 35.3 ± 22.7 | 1.32868067 | t = –0.672 | 0.521405 | 0.848722 | 683470 |
| Fractalkine | 1130.84(826.69, 2588.39) | 879.85(779.54, 1895.16) | 0.778050805 | Wilcoxon W = 16 | 0.547619 | 0.848722 | 89808 |
| MCP-1 | 79.53(24.26, 161.42) | 119.8(29.26, 372.45) | 1.506219934 | Wilcoxon W = 9 | 0.547619 | 0.848722 | 24770 |
| IL-4 | 0.06 ± 0.08 | 0.09 ± 0.05 | 1.401720264 | t = -0.6091 | 0.56102 | 0.848722 | 287287 |
| Notch-1 | 271.33 ± 150.9 | 283.29 ± 147.24 | 1.044064267 | t = –0.1268 | 0.902226 | 1 | 25496 |
| B7-1 | 0(0, 0.37) | 0(0, 0.33) | 1 | Wilcoxon W = 13 | 1 | 1 | 25408 |
| B7-2 | 0(0, 6.95) | 0(0, 16.11) | 1 | Wilcoxon W = 12 | 1 | 1 | 56822 |
| Fit-3 Ligand | 0.66(0, 2.1) | 0.65(0, 2.36) | 0.979628446 | Wilcoxon W = 13 | 1 | 1 | 1.04E + 08 |
| IL-10 | 0(0, 11.54) | 0(0, 3.16) | 1 | Wilcoxon W = 13 | 1 | 1 | 25325 |
| Neuropilin-2 | 329.77(166.34, 1581.33) | 348.82(46.11, 1051.13) | 1.057751003 | Wilcoxon W = 13 | 1 | 1 | 81527 |
| TCK-1 | 789.04(504.99, 6581.18) | 1229.66(217.51, 3259.77) | 1.558425886 | Wilcoxon W = 13 | 1 | 1 | 246358 |
| TWEAK R | 0(0, 14.54) | 0(0, 51.69) | 1 | Wilcoxon W = 12.5 | 1 | 1 | 302965 |
| 4-1BB | 0(0, 0) | 0(0, 0) | 1 | Wilcoxon W = 12.5 | 500590 | ||
| IL-17F | 0(0, 0) | 0(0, 0) | 1 | Wilcoxon W = 12.5 | 301291 | ||
| IL-1a | 0(0, 0) | 0(0, 0) | 1 | Wilcoxon W = 12.5 | 24493 | ||
| IL-2 | 0(0, 0) | 0(0, 0) | 1 | Wilcoxon W = 12.5 | 116562 | ||
| IL-3 | 0(0, 0) | 0(0, 0) | 1 | Wilcoxon W = 12.5 | 24495 | ||
| TIM-1 | 0(0, 0) | 0(0, 0) | 1 | Wilcoxon W = 12.5 | 140898 | ||
| TNFa | 0(0, 0) | 0(0, 0) | 1 | Wilcoxon W = 12.5 | 24835 | ||
| VEGF | 0(0, 0) | 0(0, 0) | 1 | Wilcoxon W = 12.5 | 83785 |