Table 5.

The multivariable analysis of impact of variables from the first group on overall survival.

Endpoint	Variable	HR (95% CI)	P value
GpNET
OS	Age	1.11 (1–1.23)	0.05
	Age at diagnosis	0.95 (0.88–1.05)	0.31
	Sex	2.19 (0.2–24.34)	0.52
	Tumor diameter	2.27 (1.62–3.19)	0.001
	Other neoplasms	59.3 (4.88–720.85)	0.001
	Other NET	17.33 (1.56–192.49)	0.02
	Cardiovascular disease	<0.001 0.00–∞	1
SpNET
OS	Age	0.92 (0.83–1.02)	0.1
	Age at diagnosis	1.13 (1.03–1.24)	0.01
	Sex	2.86 (0.96–8.49)	0.06
	Tumor diameter	1.07 (0.89–1.28)	0.5
	Other neoplasms	1.16 (0.02–1.37)	0.1
	Cardiovascular disease	0.38 (0.10–1.52)	0.17
	Diabetes	1.44 (0.42–4.98)	0.56
	Kidney disease	1.89 (0.46–7.72)	0.38

GpNET, hereditary pancreatic neuroendocrine tumor; SpNET, Sporadic pancreatic neuroendocrine tumor. The statistically significant p values are bolded.