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RNA binding activity of PIP4K and its role in translation regulation. PIP4K from different species have RNA binding activity and bind to 3′UTR sequence. The RNA binding activity is independent of its kinase activity in PIP4K2A. PIP4K2A can specifically interact and sequester eIF4EBP1, which is a known translational repressor. This in turn makes eIF4E available for mRNA cap binding and translation initiation.
