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. 2021 May 28;12:704503. doi: 10.3389/fphar.2021.704503

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Copyright © 2021 Karim, Alkreathy, Ahmad and Khan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) G1, Day 0; Skin with normal epidermis (EP) and dermis (H&E X 100×). (B) G1, day 4: Skin with inflammatory cells (IN), collagen formation (C), neovascularization (arrowhead) and ulceration (U) (H&E X 100×). (C) G2, Day 4: Skin with inflammatory cells (IN) and collagen formation (C) (H&E X 100×) (D) G3, Day 4: Skin with inflammatory cells (IN), collagen formation (C) and fibroblast proliferation (F) and neovascularization (arrowhead) (H&E X 100×). (E) G1, Day 7: Skin with inflammatory cells (IN), collagen formation (C), fibroblast proliferation (F) and neovascularization (arrowhead) (H&E X 100×). (F) G2, day 7: Skin with inflammatory cells (IN), granulation tissue (G), fibroblast proliferation (arrow), neovascularization (arrowhead) and immature epidermis (IE) (H&E X 100×). (G) G3, Day 7: Skin with inflammatory cells (IN), collagen formation (C), granulation tissue (G), fibroblast proliferation (arrow), neovascularization (arrowhead) and immature epidermis (IE) (H&E X 100×). (H) G1, Day 14: Skin with inflammatory cells (IN), collagen formation (C), neovascularization (arrowhead) and immature epidermis (IE) (H&E X 100×). (I) G2, Day 14: Skin with inflammatory cells (IN) and collagen formation (C) (H&E X 100×). (J) G3, Day 14: Skin with inflammatory cells (IN), collagen formation (C), granulation tissue (G), fibroblast proliferation (arrow), neovascularization (arrowhead) and immature epidermis (IE) (H&E X 100×). (K) G1, Day 21: Skin with inflammatory cells (IN), collagen formation (C), granulation tissue (G), fibroblast proliferation (arrow), neovascularization (arrowhead) and immature epidermis (IE) (H&E X 100×). (L) G2, Day 21: Skin with inflammatory cells (IN), collagen formation (C), granulation tissue (G), fibroblast proliferation (arrow), neovascularization (arrowhead) and immature epidermis (IE) (H&E X 100×). (M) G3, Day 21: Skin with inflammatory cells (IN), granulation tissue (G), neovascularization (arrowhead) and immature epidermis (IE) (H&E X 100×).