Table 1.

The name and biological significance of the potential hub-nodes

Hub-Proteins	Name	Functions	UniProt ID	References
SOCS3	Suppressors of cytokine signaling 3	SOCS3 is a negative regulator of the JAK–STAT signaling pathway. It promotes macrophage polarization that plays a key role in lung inflammation as well as in LC	O14543	[47]
TLR2	Toll-like receptor 2	TLR2 recognizes viral proteins and involves in APC activation. It may also recognize Spike of SARS-CoV-2. In type 1 diabetes, TLR2 signaling modulates CD4 + CD25+ Tregs and promotes inflammation to prevent diabetes	O60603	[48, 49]
BIRC3	Baculovial inhibitor of apoptosis (IAP) repeat-containing 3	BIRC3 is a member of the IAP protein family. It plays a crucial role in NF-κB signaling pathway. It is upregulated in glioblastoma which causes therapeutic resistance	Q13489	[50–52]
PPARGC1A	Peroxisome proliferator-activated receptor-gamma coactivator-1α	PPARGC1A plays a vital role in myocardial energy metabolism. In hypertensive individuals, the PPARGC1A Gly482Ser polymorphism is engaged in hypertrophy and diastolic dysfunction which may incline to heart failure. The upregulation of PPARGC1A also facilitates LC metastasis	Q9UBK2	[53, 54]
HELZ2	Helicase with zinc finger 2	HELZ2 modulates the activity of IFN to counteract viral infection. Also, it is a transcription coactivator of PPAR-γ, and HELZ2-deficient mice exhibited improved insulin resistance through enhancing lipid burning in the liver	Q9BYK8	[55, 56]
IRF7	Interferon regulatory factor 7	IRF7 is an authentic target of p53 to produce type 1 interferon upon viral infection. It is upregulated in COVID-19 and also facilitates the progression of LC	Q92985	[57, 58]