Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 2;1(1):ltab013. doi: 10.1093/immadv/ltab013

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Immunology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 1. — Schematic of SARS-CoV-2 infection in the lung. SARS-CoV-2 infection of airway epithelial cells and macrophages causes an upregulation of glycolysis and fatty acid synthesis (FAS), to enable viral replication and release of SARS-CoV-2. Viral sensing by PRRs causes interferon production, while increased glycolysis and FAS induces inflammatory cytokine production. Macrophages can be infected by SARS-CoV-2 in the same mechanism or can be polarised by inflammatory cytokines produced by airway epithelial cells. M1-like polarisation of macrophages causes the production of inflammatory cytokines that contribute to the immunopathology seen in COVID-19. Created with Biorender.com.