Fig. 7.

Effects of dorsal root ganglion stimulation and spinal cord stimulation on rats with monosodium iodoacetate-induced osteoarthritis pain. The time course for effects are shown in the left panels, and area under curve analysis for group comparisons are shown in the right panels, for plantar sensitivity to noxious mechanical stimuli (pin [A, B]), plantar sensitivity to threshold mechanical stimuli (von Frey [C, D]), and weight-bearing asymmetry (E, F). Solid arrows in A, C, and Erepresent intraarticular injection of monosodium iodoacetate and stimulation electrodes implantation. Results in A are median ± interquartile range. Results in other panels are mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 by the Tukey test after one-way ANOVA. 1, P < 0.05; 2, P < 0.01; and 3, P < 0.001 compared to data immediately before dorsal root ganglion stimulation; a, P < 0.05, b, P < 0.01, and c, P < 0.001 compared to Sham treatment group by the Dunnett test after two-way repeated measures ANOVA with Greenhouse–Geisser correction; n, number of animals.