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. 2021 May 28;11:658203. doi: 10.3389/fcimb.2021.658203

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Copyright © 2021 Jia, Liao, He, Zheng, Tong, Xue, Zhang, Yuan, Zhang and Jia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The different analysis of microbial community functions between never smokers and smokers (KEGG pathways average relative abundance > 1%). Difference in mean proportion for pathways showing significant difference in abundance are shown. The 95% confidence intervals and statistical significance (FDR q-value) are indicated as well. (B) Heatmap of spearman correlation between differentially abundant genera and above-mentioned pathways. (C) Heatmap of spearman correlation between differentially abundant species and above-mentioned pathways. The strength of the color depicts the Spearman’s correlation coefficients (negative score, blue; positive score, red). *P < 0.05, **P < 0.01.