Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 25;15:662005. doi: 10.3389/fnins.2021.662005

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Grigorescu, Vanes, Uus, Batalle, Cordero-Grande, Nosarti, Edwards, Hajnal, Modat and Deprez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Language composite score against predicted left and right frontal cortical thickness measures before and after harmonizing the tissue segmentation maps. Without harmonization (columns 1 and 3) there appears to be a significant association between left or right frontal cortical thickness and language abilities, but after harmonization (columns 2 and 4) the effect of cortical thickness on language ability is rendered non-significant in both left and right frontal cortex. This demonstrates the importance of data harmonization without which pooling images from separate datasets can lead to spurious findings that are driven by differences in acquisitions rather than by true underlying effects.