Figure 2.

Progression in a patient treated with CAR T-cell therapy. 68 year-old patient with past medical history of DLBCL diagnosed one year prior to treatment initiation. Patient had Stage IV disease, with rearrangement of the MYC and BCL6 genes, and treated with two prior lines of chemotherapy. Black (on Maximum Intensity Projection) and white arrows (on axial fusion images) show infradiaphragmatic lymphadenopathies, with muscular infiltration. Baseline imaging showed high tumor volume which is typically associated with unfavorable outcome and lower response rate to CAR T-cell therapy. Follow-up imaging showed a progression on CT-scan as well as on [18F]-FDG PET. At month-1, there were new lesions as well as an increase in tumor volume. The prognosis was poor; hence salvage treatment and later best supportive care were initiated. Patient died at month-2.