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. 2021 Jun 1;17(6):e1008996. doi: 10.1371/journal.pcbi.1008996

Fig 4. Recovery of activity over time: population firing characteristics.

Fig 4

(A) shows the coefficient of variation (CV) of the inter-spike intervals of neurons in the LPZ-C and peri-LPZ. (B) shows the average pairwise cross-correlation between neurons in the LPZ-C and peri-LPZ calculated over 5 ms bins [43]. (dotted horizontal line is y = 0.1); (C) shows spike times of neurons in the LPZ C and peri-LPZ over a 1 s period at t = {1500 s, 2001.5 s, 4000 s, 18,000 s}. The network is permitted to achieve its balanced Asynchronous Irregular (AI) low frequency firing regime under the action of inhibitory synaptic plasticity (t ≤ 1500 s). At (t = 2000 s), neurons in the LPZ are deafferented (panel 2 in B is at t = 2001.5 s) and the network allowed to repair itself under the action of our structural plasticity mechanism (panels 3 (t = 4000 s) and 4 (t = 18,000 s) in B). As can be seen here, the network does not return to its AI state after repair (graphs are discontinuous because ISI CV and CC are undefined in the absence of spikes).