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. Author manuscript; available in PMC: 2021 Jun 11.
Published in final edited form as: Biochemistry. 2019 Nov 26;58(49):4903–4911. doi: 10.1021/acs.biochem.9b00854

Figure 4.

Figure 4.

Properties of IQ motifs binding to Ca2+-CaM. Snapshots of Ca2+-CaM interacting with (A) IQ1, (B) IQ2, (C) IQ3, and (D) IQ4 motifs, displayed by a cartoon depicting the Ca2+-CaM–IQ interaction mode. (E) RMSF values of Ca2+-CaM and (F) interface areas between IQ motifs and Ca2+-CaM in the Ca2+-CaM–IQ complexes. The figure shows that the conserved basic and hydrophobic residues, especially the “I” of IQ (Leu752 for IQ1, Ile782 for IQ2, Ile812 for IQ3, and Ile842 for IQ4), exhibit significant Ca2+-CaM–IQ interactions. The blue dots denote the Ca2+ in the complexes.