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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Ann Neurol. 2021 Apr 22;89(6):1129–1144. doi: 10.1002/ana.26070

FIGURE 4:

FIGURE 4:

Expression of Prolactin and prolactin receptor in mouse dura. A 3 x 3 mm square area of dura mater from 5-week-old female (A), 10-week-old female (B) and 10-week-old male (C) Prlrcre/-/TdT mice. Green arrows mark Prlr-cre+non-neuronal cells. Blue arrows mark Prlr-cre+dural afferent fibers. Objective (10x, scale bars represent 120 μm). Dura mater from 10-week-old female Prlrcre/-/TdT mice labeled with anti-CGRP and anti-CD31 antibodies (D). Pink arrows show dural blood vessel co-expressing Prlr-cre+(Green) and CD31 + (Red) cells. Objective (20x, scale bars = 120 μm). Prlr-cre+dural afferent fibers express CGRP (Blue) and are indicated with yellow arrows (E). White arrows mark Prlr-cre+ expression on non CGRP expressing dural fibers (E'). Objective (20x). PRL (F, F'), CGRP (G, G'), and TH (H, H') expression in female mouse dura. Overlap of (F-H) shown in (I). For 40x images scale bars represent 100 μm.