Fig. 1. Platform for the molecular-scale spatial control of two extracellular ligands.

(A and B) Schematic representation of ligand patterns in which colocalized or spatially segregated ligands, respectively, control the spatial arrangement of integrating receptors (not to scale). (C) Scheme of a ligand pattern that controls activating-inhibitory balance in NK cells. PEG, polyethylene glycol. (D and E) False-colored scanning electron micrograph of NK cells stimulated in activating-inhibitory ligand array with different spacings between the ligands. Scale bars, 5 μm; scale bars in high-magnification images, 200 nm.