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. Author manuscript; available in PMC: 2021 Jun 11.
Published in final edited form as: ACS Appl Bio Mater. 2020 Mar 3;3(4):1976–1985. doi: 10.1021/acsabm.9b01141

Figure 4.

Figure 4.

APN reduces infarct volumes, neurological deficits, and delayed tPA-induced intracerebral hemorrhage after tMCAO in mouse. (A) Representative images of TTC-stained brain coronal sections of mice in indicated groups 3 days after tMCAO. (B) Quantitative analysis of infarct volumes. (C, D) Neurological deficits were evaluated with the (C) Bederson test and the (D) grip test 3 days after tMCAO. n.s. indicates not statistically significant. (E) Representative images of unstained coronal sections (left) showing intracerebral hemorrhage (red color) induced by delayed tPA and quantitative analysis of hemorrhage volume (right) in indicated groups 1 day after tMCAO. n.s. indicates not statistically significant.