Table 3.

Univariate and multivariate analysis of overall survival in 49 patients with hilar cholangiocarcinoma according to clinicopathological factors and AKR1C1 overexpression.

Clinicopathological factor	Case (n)	OS(mo)	Univariate analysis		Multivariate analysis
			χ2	P	χ2	P	HR(95%CI)
T stage
T1-3	7	50	7.559	0.006	6.172	0.013	0.153(0.035-0.672)
T4	42	16
N stage
No	16	42	5.602	0.018	3.343	0.067	0.459(0.199-1.058)
Yes	33	14
Differentiation
High/moderate	37	23	3.640	0.056		NA
poor/un-differentiated	12	16
Positive margin
No	23	26	4.096	0.043		NA
Yes	26	16
AKR1C1
Negative	19	50	24.923	<0.001		NA
Positive	30	13