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. 2021 May 12;40(23):3929–3941. doi: 10.1038/s41388-021-01798-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — MDA-MB-231 cells carrying shERK5i were orthotopically transplanted into the mammary fad pad of CD1 nude mice. A Representative bioluminescence images of mammary tumors just before (day 20) and after mice were fed with doxycycline for 12 and 22 days. B Tumors were measured on average twice a week for the duration of the experiment. The data presented as fold increase in the volume of tumor size after the introduction of the dox diet at day 20 correspond to the mean ± SD. After 4 weeks, animals in the dox− and dox+ cohorts exhibiting large tumors or a change in normal behavior were humanely culled. Total N number of animals analyzed per condition over the duration of the experiment is indicated. C Tumors were collected 4 weeks after exposure to doxycycline and analyzed by immunohistochemistry with a specific antibody to ERK5 or to p-FAK(Y397). Scale bars: (40x) 20 μm.