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. 2021 May 12;40(23):3929–3941. doi: 10.1038/s41388-021-01798-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Control (dox−) and doxycycline-fed (dox+) mice bearing mammary tumor grafts were paired according to similar tumor size. A, B Breast metastasis was detected post mortem by quantification of live (DAPI⁻) breast cancer cells (tdT⁺) in the lung. A representative flow cytometry analysis is shown in B. The graphical analysis of the data demonstrated that ERK5 knockdown significantly reduced metastatic burden. Ratio paired t test was applied for p value calculation, p ≤ 0.01 (**). Raw numbers utilized for the graph are presented in the table. C Breast metastasis to the spleen and bone were detected by bioluminescence imaging in one control (dox−) animal of a pair sacrificed at 4 weeks after dox exposure.