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. 2021 May 20;40(23):4033–4049. doi: 10.1038/s41388-021-01824-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — FMRP in invading iCCA cells could regulate local metabolism (mRNA stability, transport, translation etc.) of specific mRNAs (such as Cortactin or MMP mRNAs) in invadopodia, favoring invadopodia formation and membrane plasticity at the leading edges of cancer cells during invasion processes (left panel with enlarged box). Silencing of FMRP reduced cell invasiveness, reducing their front-rear morphology and their ability to migrate and to degrade the ECM (right panel).