Table 2.
Multivariate analysis of outcomes based on patient, disease, and transplant characteristics
| Variable | Grade III–IV aGVHD | cGVHD†* | OS | GRFS | IRM | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Univariate | Multivariate | Univariate | Multivariate | Univariate | Multivariate | |||||||||
| p | sHR | 95% CI | p | p | p | HR | 95% CI | p | p | HR | 95% CI | p | p | sHR | 95%CI | p | |
| Age, years§ | 0.23 | 0.76 | 0.12 | 0.55 | 0.004 | 1.04 | 1.02–1.07 | 0.002 | |||||||||
| Male gender | 0.82 | 0.21 | 0.70 | 0.72 | 0.26 | ||||||||||||
| Active disease | 0.12 | 0.07 | <0.001 | 2.13 | 1.61–2.82 | <0.001 | <0.001 | 2.11 | 1.61–2.76 | <0.001 | <0.001 | 2.46 | 1.41–4.28 | 0.002 | |||
| RIC | 0.78 | 0.13 | 0.27 | 0.99 | 0.72 | 0.54–0.96 | 0.023 | 0.005 | |||||||||
| BM graft | 0.80 | 0.83 | 0.28 | 0.17 | 0.22 | ||||||||||||
| Female to male D/R | 0.52 | 0.052 | 0.61 | 0.77 | 0.73 | ||||||||||||
| HLA mismatch | <0.001 | 3.17 | 1.76–5.70 | <0.001 | 0.35 | 0.12 | 0.073 | 0.29 | |||||||||
| High ATG dose | 0.25 | 0.35 | 0.052 | 0.014 | 1.37 | 1.06-1.78 | 0.015 | 0.019 | 2.05 | 1.14–3.68 | 0.016 | ||||||
Values in bold are significant p values
*Moderate–severe
†No significant association by multivariate analysis
§As continuous variable, analyzed by Cox model; BM bone marrow, D/R donor/recipient, GVHD Graft-versus-host disease, OS overall survival, GRFS GVHD/relapse-free survival, HR hazard ratio, IRM infection-related mortality, RIC reduced intensity conditioning, sHR sub-hazard ratio