Table 5.
Multi-level multivariable logistic regression analysis of risk factors for overall mortality during follow-up of patients with IEP or BS
| IEP (n = 576) | Adjusted* | BS (n = 384) | Adjusted* | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Risk factor | Yes | No | p | OR | 95%CI | p | Yes | No | p | OR | 95%CI | p |
| Overall mortality | ||||||||||||
| Age ≥ 70 | 35 (15%) | 20 (6%) | < 0.001 | 2.9 | 1.5–5.7 | 0.002 | 41 (30%) | 24 (10%) | < 0.001 | 5.9 | 3.0–11.5 | < 0.001 |
| Male gender | 35 (11%) | 20 (8%) | 0.358 | 1.5 | 0.8–2.7 | 0.197 | 52 (18%) | 13 (13%) | 0.223 | 0.5 | 0.3–1.1 | 0.107 |
| Proximal location | 23 (8%) | 32 (12%) | 0.132 | 1.8 | 1.0–3.3 | 0.064 | 13 (20%) | 51 (16%) | 0.488 | 1.0 | 0.4–2.5 | 0.975 |
| Initial treatment | ||||||||||||
| Surgery only | 28 (10%) | 27 (9%) | 0.511 | 0.3 | 0.1–0.9 | 0.026 | 32 (14%) | 33 (22%) | 0.043 | 1.2 | 0.4–3.7 | 0.811 |
| Endoscopy only | 10 (7%) | 45 (10%) | 0.278 | 0.2 | 0.1–0.7 | 0.011 | 8 (15%) | 57 (17%) | 0.750 | 0.9 | 0.2–3.5 | 0.913 |
| Conservative only | 10 (7%) | 45 (10%) | 0.291 | 0.3 | 0.1–0.9 | 0.028 | 20 (36%) | 45 (14%) | < 0.001 | 3.4 | 0.9–12.3 | 0.060 |
| Surgery and endoscopy | 7 (23%) | 48 (9%) | 0.008 | – | – | – | 5 (12%) | 60 (18%) | 0.325 | – | – | – |
Bold p-values indicate that differences between the groups were statistically significant
−Could not be estimated due to limited data
n, number of patients, IEP iatrogenic esophageal perforation, BS Boerhaave’s syndrome, OR odds ratio, CI confidence interval, ICU intensive care unit
*Analysis is adjusted for age, gender, location of perforation, initial treatment modality and center of treatment